MicroRNAs meet calcium: Joint venture in ER proteostasis
نویسندگان
چکیده
منابع مشابه
ER strikes again: Proteostasis Dysfunction In ALS.
The precise contribution of endoplasmic reticulum (ER) chaperone protein disulfide isomerase (PDI) variants in human amyotrophic lateral sclerosis (ALS) patients to the pathogenesis of ALS remained unclear. In the present study, Woehlbier et al (2016) demonstrated that these PDI variants are capable of altering motor neuron morphology, impairing the expression of synaptic proteins, and compromi...
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Project Description: The Great Salt Lake (GSL) is the fourth largest terminal lake in the world and is an important region for breeding and migratory waterbirds and wintering common goldeneye (Aldrich and Paul 2002, J. Vest unpublished data). Because the GSL is a closed basin, contaminants (e.g., mercury, selenium, cadmium, and others) associated with industrial and urban development in the Sal...
متن کاملSea Duck Joint Venture
Principal Investigators: Jean-Michel DeVink, University of Saskatchewan, 115 Perimeter Rd, Saskatoon, Saskatchewan, S7N 0X4, jean-michel.devink@ec.gc.ca Dr. Stuart Slattery, Ducks Unlimited Canada, Institute for Wetland and Waterfowl Research, Box 1160, Stonewall, Manitoba, R0C 2Z0, s_slattery@ducks.ca Dr. Bob Clark, Canadian Wildlife Service, 115 Perimeter Rd, Saskatoon, Saskatchewan, S7N 0X4,...
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Little is known about where microRNAs (miRNAs) regulate their targets within the cell. In this issue, Li et al. identify a new player in the plant miRNA pathway that implicates the endoplasmic reticulum in miRNA-mediated gene silencing.
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Parkinson’s disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc). Proteostasis impairment at the level of the endoplasmic reticulum (ER) is emerging as a driving factor of dopaminergic neuron loss in PD. ER stress engages the activation of an adaptive reaction known as the unfolded protein response (UPR) to recover proteostasis...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2014
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.2005671